OMAHA, Neb. — Audrey Faber and Jaylyn Agnew each scored 19 points and Creighton upset No. 18 Villanova 69-54 Thursday in a Big East Conference opener to give coach Jim Flanery his 300th program win.

Sydney Lamberty’s 3-point play off a layup put Creighton (7-4) ahead 39-36 with 5:51 left in the third quarter and the Bluejays never trailed thereafter.

Villanova owned leads of 16-9 and 29-20 in the first half before Creighton began to take control and trailed 33-32 at intermission. Villanova (10-1) finished the second half shooting just 8 for 23 from the field including 2 for 9 from beyond the 3-point arc.

Creighton controlled the interior and outscored the Wildcats 36-24 inside and scored 20 points off 10 Villanova turnovers. Creighton outrebounded Villanova 35-28. The Bluejays shot 49 percent (27 of 55).

Megan Quinn and Jannah Tucker led Villanova (10-1) with 11 points each and Adrianna Hahn scored 10.