MADRID — Real Madrid will be without central defender Sergio Ramos and midfielder Isco for Saturday’s Spanish league match at Valencia because of injury.

Madrid said on Friday that Ramos has pulled a muscle in his left leg, while Isco has a pinched nerve in his left thigh.

Madrid is in a fight to ensure a top-four finish. It trails third-place Valencia by five points — albeit with a game in hand — and has Villarreal one point behind in fifth.

Madrid visits Valencia’s Mestalla Stadium three days after a shock loss to Leganes sent it tumbling out of the Copa del Rey quarterfinals.