Work at the Interstate 65 and State Road 46 interchange will resume at 7 p.m. today and continue through noon Monday.
The work on I-65 is between County Road 100N and Carr Hill Road. There will be alternating lane closings on the interstate throughout the weekend, according to the Indiana Department of Transportation.
Both the entrance and exit ramps for southbound I-65 will have lane closings on the ramps, but the ramps will not be fully closed.
The I-65 northbound driving lane will be closed for part of the weekend.
Crews will add pavement markings, raised pavement markers, complete concrete patching and finish cleanup.
There will be signs, changeable message boards, flashing arrow signs and barrels for traffic control.